Fasting, the new health mantra

Fasting may not be just a religious or political practice. It may actually protect you against age-related diseases and improve your overall health, researchers say.

The study, led by a team from the University of California-Irvine (UCI), found that fasting affects circadian clocks in the liver and skeletal muscle, causing them to rewire their metabolism, which can ultimately lead to improved health and protection against age-related diseases.

The circadian clock operates within the body and its organs as intrinsic time-keeping machinery to preserve homeostasis in response to the changing environment.  And, while food is known to influence clocks in peripheral tissues, it was unclear until now how the lack of food influences clock function and ultimately affects the body.

"We discovered fasting influences the circadian clock and fasting-driven cellular responses, which together work to achieve fasting-specific temporal gene regulation," said lead author Paolo Sassone-Corsi, Professor of Biological Chemistry at UCI.  "Skeletal muscle, for example, appears to be twice as responsive to fasting as the liver," Sassone-Corsi added.

"Optimal fasting in a timed manner would be strategic to positively affect cellular functions and ultimately benefiting health and protecting against age-associated diseases." This study opens new avenues of investigation that could ultimately lead to the development of nutritional strategies to improve health in humans.