Brain zaps boost memory in people over 60: Study

Boston: Zapping the brains of people over 60 with a mild electrical current can improve a form of memory -- enough to make them perform like 20-year-olds -- scientists say.

Someday, people might visit clinics to boost that ability, which declines both in normal ageing and in dementias like Alzheimer's disease, said Robert Reinhart, researcher at Boston University in the US. The treatment is aimed at "working memory," the ability to hold information in mind for a matter of seconds as you perform a task, such as doing math in your head. Sometimes called the workbench or scratchpad of the mind, it's crucial for things like taking medications, paying bills, buying groceries or planning, Reinhart said in a statement.

The study is not the first to show that stimulating the brain can boost working memory. The research, published in the journal Nature Neuroscience, showed success in older people and because the memory boost persisted for nearly an hour minimum after the brain stimulation ended. "It's a superb first step" toward demonstrating a way to improve mental performance, said Barry Gordon, a professor at the Johns Hopkins School of Medicine, who was not involved in the study.

More research is needed before it can be formally tested as a treatment, researchers said. The electrical current was administered through a tight-fitting cap that also monitored each subject's brainwaves. For study participants, that current felt like a slight tingling, itching or poking sensation under the electrodes for about 30 seconds, Reinhart said. The researchers' idea was to improve communication between the brain's prefrontal cortex in the front and the temporal cortex on the left side, because the rhythms of activity in those two regions had fallen out of sync with each other.

So the researchers applied the current to those two regions to nudge the activity cycles back into a matching pattern. The results provided new evidence that a breakdown in that communication causes the loss of working memory with age, Reinhart said. Part of the study included 42 participants in their 20s, plus 42 others aged 60 to 76. First they were tested on a measure of working memory. It involved viewing an image such as a harmonica or broken egg on a computer screen, then a blank screen for three seconds, and then a second image that was either identical to the first or slightly modified.

The subjects had to judge whether it was the same image or not. During a sham stimulation, the older group was less accurate than the younger participants. However, during and after 25 minutes of real brain stimulation, they did as well. The improvement lasted for at least another 50 minutes after the stimulation ended, at which point the researchers stopped testing. It is not clear how long the benefit reached beyond that, Reinhart said, but previous research suggests it might go for five hours or more after stimulation stops. Researchers got the same result with a second group of 28 subjects over age 62.