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New test now predicts breast cancer spreading to brain
New test now predicts breast cancer spreading to brain. Researchers have developed a new tumour marker test that may help predict whether breast cancer is likely to spread or metastasise to the brain, a deadly complication.
Researchers have developed a new tumour marker test that may help predict whether breast cancer is likely to spread or metastasise to the brain, a deadly complication.
The approach was based on prior laboratory experiments by Cryns on a cell stress protein called alpha B-crystallin. For the new research, the team analysed nearly 4,000 breast tumour samples from women with long-term clinical follow up, including sites of metastasis. The researchers found that among women with metastatic disease, women whose breast tumours expressed B-crystallin were nearly three times more likely to develop brain metastasis than women whose breast tumours did not express this protein.
Alpha B-crystallin expression also predicted shorter survival after the initial breast cancer diagnosis and after the diagnosis of brain metastasis. "The results were completely consistent with our predictions based on our prior laboratory studies," study co-leader Cryns said.
Cryns said that the results have to be validated in additional studies before this test could be used in the clinic. (The findings appeared in the journal npj Breast Cancer.)
