Certain genes can lengthen lifespan, only if you exercise!

​New York: Interacting with a healthy environment that includes exercise, certain genes can play an important role in prolonging lifespan, new research has found.

The researchers studied the genes in the brain's dopamine system to assess their impact on lifespan and behaviour in mice. Dopamine is a neurotransmitter that helps control the brain's reward and pleasure centres and helps regulate physical mobility and emotional response.

The researchers found that the dopamine D2 receptor gene (D2R) significantly influences lifespan, body weight and locomotor activity, but only when combined with an enriched environment that included social interaction, sensory and cognitive stimulation and, most critically, exercise.

"The incorporation of exercise is an important component of an enriched environment and its benefits have been shown to be a powerful mediator of brain function and behaviour," said lead researcher Panayotis (Peter) K. Thanos from Research Institute on Addictions, University at Buffalo in New York.

The researchers found that the mice in the enriched environment lived anywhere from 16 to 22 percent longer than those in a deprived environment, depending on the level of D2R expression.