Why medication fails to address mood disorders

Why medication fails to address mood disorders
Highlights

The majority of people with mood and anxiety disorders who receive the most commonly prescribed anti-depressants -- called SSRIs -- are not helped by these medications. A new research sheds light on why Selective Serotonin Reuptake Inhibitors or SSRIs fail to work in most patients. SSRIs are designed to increase serotonin, a neurotransmitter in the brain that is key to maintenance of mood.

New York: The majority of people with mood and anxiety disorders who receive the most commonly prescribed anti-depressants -- called SSRIs -- are not helped by these medications. A new research sheds light on why Selective Serotonin Reuptake Inhibitors or SSRIs fail to work in most patients. SSRIs are designed to increase serotonin, a neurotransmitter in the brain that is key to maintenance of mood.

The researchers advocate that additional studies should be performed as better understanding of the serotonin system will significantly improve future treatment options. Coplan noted that a recent large-scale study showed only a minority of patients do well on SSRIs, and of those, many lose response in a year or two.

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