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GENOME –WIDE ANALYSIS CORRELATES AYURVEDA PRAKRITI GENOMICS AND THE THREE DOSHAS OF AYURVEDA
Highlights
A genome-wide study to establish correlation between Ayurvedic prakriti classifications with genomic diversity has been done by the Centre for Cellular & Molecular Biology (CCMB), a premier research organization in frontier areas of modern biology with the collaboration of other institutes.
A genome-wide study to establish correlation between Ayurvedic prakriti classifications with genomic diversity has been done by the Centre for Cellular & Molecular Biology (CCMB), a premier research organization in frontier areas of modern biology with the collaboration of other institutes.
A research team at the CCMB under the leadership of Dr. Thangaraj, has taken up the mega program including people from different institutions. Well-trained Ayurvedic physicians screened about 3400 people and the same sets of people were also screened by software called AyuSoft developed by C-DAC, Bangalore. People whose Prakriti was in concurrence between the assessment by the Ayurvedic physician and by AyuSoft were recruited for the study. Their blood samples were collected by respective participating labs. Isolation of DNA and genomic studies were carried out at CCMB using Affymetrix 6.0 SNP chip.This chip will bring out single nucleotide difference in the genome among the tested samples. When the data is plotted, interestingly they fell into three groups, establishing the molecular basis for ancient classification.
This is the first genome-wide study to establish such correlation between Ayurvedic prakriti classifications with genomic diversity. Analysis of these SNPs revealed that about 52 genes might be responsible for specifying the individual's doshas or prakritis. Dr. Thangaraj and his group has taken this study further and attempted to see if the samples collected randomly, without any information on their prakriti, would also fall into three groups after the analysis based on the 52 SNPs, which appear to be important.
Director-CCMB Dr. Ch. Mohan Rao said that this study would help to identify the prakriti of a person based on her/his genome. “This is a major breakthrough linking our ancient wisdom with modern science”. He also said that this work will inspire many more such studies. These studies should eventually lead to establishing Ayurveda on sound footing along with modern medicine.
These studies were recently published in an Open Access Journal, Science Reports, of Nature group of publications. It can be accessed at: http://www.nature.com/articles/srep15786
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