Genetic similarity in spouse may help you

More than you may think.

People tend to choose spouses who have similar DNA, according to scientists who reported on Monday the results of a study exploring the genetic resemblance of married couples.

The researchers examined the genetic blueprints of 825 US married couples and found a significant preference for a spouse with DNA similarities across the entire human genome.

The study compared this affinity for husbands or wives with similar DNA makeup to the well-established and strong tendency of people to marry mates with similar educational levels.

The researchers found that the preference for a genetically similar spouse was about a third as strong as the preference for a spouse with comparable education.

The 1,650 people studied in the research were non-Hispanic, white men and women born between the 1930s and 1950s who were taking part in a broader US government-funded study involving health and retirement.

"We do know in some sense that people prefer genetically similar spouses because we know that people tend to date and marry within their own racial and ethnic groups. We worked really hard in this study to not just replicate that fact," said researcher Benjamin Domingue of the University of Colorado's Institute of Behavioral Science, who led the study. "We eliminated racial variability and tried to control for ethnic variability. And we still find a preference for genetically similar individuals," Domingue added.

The researchers measured genetic similarity by comparing 1.7 million individual DNA building blocks, known as single nucleotide polymorphisms, in the study participants. They compared the genetic makeup of the married couples to other randomly chosen people of the opposite sex in the same pool of study participants.

Domingue said the actual mechanism for a person being drawn to another person's genetic similarities is probably complicated and multifaceted - "just a whole host of things," he noted.

The researchers noted that people usually pick spouses with similar backgrounds and characteristics in addition to education, including race, religion, age, income and body type. Genetic similarity can be added to the list, they said.

"For example, people clearly care about height in picking partners. To the extent that tall people marry other tall people, that is going to result in genetic similarity among spouses. But it is difficult to know whether height or genes is driving this decision," Domingue said.

The researchers said it would be interesting to see the results of similar studies involving other populations including additional races, interracial spouses and gay couples.